La Salle, IL is a city located in La Salle County, Illinois and has a land area of 42.25 square miles (109.43 km2). The water area for the city is 0.39 square miles or 1.01 km2. There is one unique zip code in La Salle, Illinois and it is 61301. The area code(s) for La Salle is 815/779.
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